Endocrine Abstracts

Objective: PWS is associated with hypogonadism and partial GH insufficiency. In addition partial insufficiency of the hypothalamic–pituitary–adrenal (HPA) axis recently was suggested (de Lind van Wijngaarden 2008) based upon an insufficient response to an overnight single-dose metyrapone in 15 out of 25 (60%) children. We aimed at further exploring this potentially dangerous condition.Methods: During a 1-year period genetically verified PWS pat...

Introduction: Prader–Willi syndrome (PWS) presents clinically with a multitude of findings, including abnormal body composition and partial GH deficiency. Until now three studies have reported beneficial effects upon body composition of GH treatment in adults with PWS. However, only one of these studies had the optimal randomised controlled design.Aim: The aim of this study was to confirm and substantiate the results from previous studies.<p cla...